Karen Nichols, ARNP - Aging Gracefully & Living Happily
(located in the Avondale area of Everett, WA)
What is Xeomin?

Xeomin forehead B&AXeomin® is the newest “frown fixer” available in the United States.  Pronounced zee-oh-min, the new product acts like its predecessors, Botox and Dysport, in reducing or preventing contractions of the glabellar muscle between the eyes.

How is Xeomin different from Botox or Dysport?

The difference in Xeomin® (incobotulinumtoxin A) is that it does not carry the proteins that are typical of the other products. The potential advantage lies in the lessened likelihood of antibodies being formed to the proteins which – for a very limited number of patients – can render the product ineffective. (This typically is only seen in patients who have used botulinum toxin for an extended period of time.)

Xeomin® claims be an innovative Botulinum type A formulation, in which the complexing proteins have been removed by an extensive purification process from the botulinum toxin complex. In contrast to the other commercially available preparations, Xeomin® contains the pure 150 kD neurotoxin.

It is widely accepted that the bacterial protein present in other products play a role as promoters of an immune reaction, resulting in a loss of effect and reduction in duration of activity. Studies show that Xeomin®, without the complexing proteins, has the lowest content of protein of all of the available botulinum toxins and furthermore show that repeated application of Xeomin®, even in high doses, does not induce the formation of neutralizing antibodies.

This means that Xeomin® is able to provide similar results to those achievable with the other products without the risk of antibody formation, providing continual long lasting effects. This could be relevant when large doses are being used for medical indications, but many industry experts questions the relevance when this product is used for cosmetic purposes.

picture of xeomin in a bottle, not yet mixed up.  Box is behind the bottle. Cosmetic use for wrinkles by Karen Nichols, ARNP, in Kirkland, WA

How is Xeomin® Similar to Botox or Dysport?

The muscle-restricting action is, for all practical purposes, like Botox and Dysport and the dosing will be the same as Botox. So if you're accustomed to 20 units of Botox, expect to receive 20 units of Xeomin® the same effect and area.

How fast does Xeomin® work?

Although still very new to the U.S. market, Xeomin® is reported to begin taking effect within 2-3 days after injection with effectiveness ranging up to 4 months.
Xeomin man brows B&A

FDA Approval of Xeomin

The FDA approval of Xeomin® for cosmetic use is based on the results of two pivotal U.S. clinical trials involving 16 investigational sites and included 547 healthy adult patients. In both studies, Xeomin® significantly improved the appearance of glabellar lines 30 days following the first injection, when compared to placebo. Xeomin® is the only botulinum toxin currently approved in the U.S. that does not require refrigeration prior to reconstitution.

Elsewhere in the world, Xeomin® has been -- 
  • approved in Europe since 2005      
  • used for medical treatment of blepharospasm and cervical dystonia
  • treated more than 84,000 patients worldwide
  • used in 20 countries under the name BOCOUTURE®. 

Who Should NOT Have Xeomin Treatment?
  • Individuals with a known hypersensitivity to any component of the formulation.
  • Patients who have generalized disorders of muscle activity (e.g. myasthenia gravis).
  • Patients where aminoglycoside antibiotics or spectinomycin are already being used or are likely to be used.
  • Patients who have bleeding disorders of any type.Pregnant or lactating women.
  • See Safety Warnings for more information.